Tell your doctor if you are pregnant or breastfeeding. Applies to: Autonomic Neuropathy. We comply with the HONcode standard for trustworthy health information -, Drug class: anticholinergics/antispasmodics. Antimuscarinics (Includes hyoscyamine) ↔ coronary artery disease. Applies to: Glaucoma/Intraocular Hypertension. Gate Pharmaceuticals, Sellersville, PA. "Product Information. Clin Pediatr (Phila) 24 Pacing Clin Electrophysiol 5 It is also used to treat other conditions such as bladder and bowel control problems, cramping pain caused by kidney stones and gallstones. (1971): 13-34. A drug interaction effect on the gastro-oesophageal sphincter in man." others, such as amantadine, belladonna-containing medicines, macimorelin, or potassium supplements. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Hyoscyamine is used to treat a variety of stomach/intestinal problems such as cramps and irritable bowel syndrome. (1974): 661-4, Goldstein JH "Effects of drugs on cornea, conjunctiva, and lids." High blood pressure (hypertension) and diabetes are the most common causes of kidney disease. Kidney disease is most often caused by other conditions that put a strain on the kidneys. (1978): 366-70. Hyoscyamine sulfate is partly hydrolyzed to tropic acid and tropine but the majority of the drug is excreted in the urine unchanged within the first 12 hours. Applies to: Hyperthyroidism. Levsin SL (Hyoscyamine Sulfate) works by decreasing acid production in the stomach. (1976): 1186-90, Howells TH "The administration of metoclopramide with atropine." Section II: Anticholinergic drugs." It blocks the action of acetylcholine at parasympathetic sites in sweat glands, salivary glands, stomach secretions, heart muscle, sinoatrial node, smooth muscle in the gastrointestinal tract, and the central nervous system. Wyeth-Ayerst Laboratories, Philadelphia, PA. "Product Information. The basic uses of these two drugs are quite similar. Anticholinergics may further suppress intestinal motility with resultant precipitation or aggravation of toxic megacolon. This alkaloid is also useful for fighting certain Parkinson’s disease symptoms. Can Med Assoc J 128 Available for Android and iOS devices. These drugs should be administered cautiously to patients with ulcerative colitis. Moban (molindone)." medicines that affect the heart's rhythm, such as amiodarone, dofetilide, dronedarone, pimozide, quinidine, sotalol, or procainamide. Levsin (hyoscyamine) is classified as an anticholinergic-sedative. Glaxo Wellcome, Research Triangle Park, NC. Marezine (cyclizine)." Optimine (azatadine)." Applies to: Bleeding. "Product Information. Postgrad Med 79 "Product Information. Antivert (meclizine)." Muscarinic receptor antagonists reduce bronchial secretions, which can result in decreased fluidity and increased thickening of secretions. Therapy with anticholinergics should be administered cautiously in patients with hyperthyroidism. In addition to theses, this medicine is considered good for Parkinson’s disease. Their use may be appropriate to reduce adverse muscarinic effects caused by an anticholinesterase agent. JAMA 241 Therefore, these drugs should be administered cautiously in patients with diarrhea. (1985): 613-4, Berdy GJ, Berdy SS, Odin LS, Hirst LW "Angle closure glaucoma precipitated by aerosolized atropine." Brown JW "Toxic megacolon associated with loperamide therapy." Acta Med Scand 199 Major Potential Hazard, Moderate plausibility. Hyoscyamine may also be used to treat rhinitis. Int Ophthalmol Clin 11 Applies to: Myasthenia Gravis. Atropine-like agents may increase the risk of hyperthermia in patients with fever by producing anhidrosis. The half-life of hyoscyamine sulfate is 2 to 3 1/2 hours. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension. (1991): 1403-4, Nahata MC, Clotz MA, Krogg EA "Adverse effects of meperidine, promethazine, and chlorpromazine for sedation in pediatric patients." Hyoscyamine is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson's disease. Hyoscyamine is sometimes used to … New York, NY: McGraw-Hill Health Professionals Division Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. Select one or more newsletters to continue. Cogentin (benztropine)." Am J Cardiol 36 Med Lett Drugs Ther 19 Thorazine (chlorpromazine)." JACEP 7 We comply with the HONcode standard for trustworthy health information -, https://www.drugs.com/ppa/hyoscyamine.html, Drug class: anticholinergics/antispasmodics, Hyoscyamine Orally Disintegrating Tablets. (1975): 281-5, Lunde P "Ventricular fibrillation after intravenous atropine for treatment of sinus bradycardia." Talk to your doctor urgently if you experience unexplained diarrhea, eye pain, a fast or irregular heartbeat, or develop a skin rash. JAMA 228 Major Potential Hazard, High plausibility. ESI Lederle Generics, Philadelphia, PA. "Product Information. Minor Potential Hazard, Low plausibility. Am J Gastroenterol 70 Can decrease the incidence of rhinitis (a runny nose) and reduce excessive production of saliva. Applies to: Diarrhea. Applies to: Liver Disease. Ann Ophthalmol 6 It is also used to treat other conditions such as bladder and bowel control problems, cramping pain caused by kidney stones and gallstones, and Parkinson's disease. Hyoscyamine inhibits the action of acetylcholine, the main neurotransmitter of the parasympathetic nervous system. Acta Anaesthesiol Scand 28 Merck & Co, Inc, West Point, PA. "Product Information. Mevorach D "Adverse effects of atropine sulfate autoinjection." Dysuria may occur and may require catheterization. Proc Soc Exp Biol Med 139 Moderate Potential Hazard, Moderate plausibility. This is because the body is usually able to cope with a significant reduction in kidney function. Compazine (prochlorperazine)." Hyoscyamine may be used in the treatment of a wide variety of gastrointestinal problems including cramps, bladder control issues, and irritable bowel syndrome. Anticholinergics work by blocking the action of the neurotransmitter acetylcholine in the brain and at nerves throughout the body. J Antimicrob Chemother 9 (1982): 209-16 Australian Drug Evaluation Committee "Adverse effects of drugs … Applies to: Arrhythmias, Ischemic Heart Disease . O'Kelly SW, Spargo PM "Postoperative urinary retention in men." Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Schering-Plough, Liberty Corner, NJ. Hyoscyamine is an antimuscarinic; i.e., an antagonist of muscarinic acetylcholine receptors. Artane (trihexyphenidyl)." Bock Pharmaceutical Company, St. Louis, MO. Therapy with anticholinergics should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. SmithKline Beecham, Philadelphia, PA. "Product Information. It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. Other brands: Levsin, Hyosyne, Levsin SL, Oscimin, ... +6 more, diazepam, oxybutynin, dicyclomine, lidocaine, Valium, fentanyl, Amitiza, simethicone, Metamucil, Bentyl. Hyoscyamine is used to treat a variety of stomach/intestinal problems such as cramps and irritable bowel syndrome. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Hyoscyamine inhibits the action of acetylcholine, the main neurotransmitter of the … Curr Med Res Opin 5 "Product Information. Moderate Potential Hazard, Moderate plausibility. Thyroid levels should be monitored if usage is prolonged. J Allergy Clin Immunol 70 "Product Information. Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. In general, the use of anticholinergic agents is contraindicated in patients with urinary retention and bladder neck obstruction caused by prostatic hypertrophy. Anaesthesia 34 (1982): 458-64. "Product Information. Hyoscyamine is used to treat many different stomach and intestinal disorders, including peptic ulcer and irritable bowel syndrome. Highly clinically significant. Anticholinergics block vagal inhibition of the SA nodal pacemaker. Postgrad Med J 66 Hyoscyamine sulfate is partly hydrolyzed to tropic acid and tropine but the majority of the drug is excreted in the urine unchanged within the first 12 hours. J Clin Psychiatry 47 Applies to: Gastroesophageal Reflux Disease. Anticholinergics work by blocking the action of acetylcholine in the brain and at nerves throughout the body. "Product Information. Therapy with antimuscarinic agents and higher dosages of antispasmodic agents (e.g., dicyclomine or oxybutynin) should be administered cautiously in patients with autonomic neuropathy. Med Lett Drugs Ther 17 It may be used to relieve gastrointestinal cramps and excessive secretions. You should not use hyoscyamine and phenyltoloxamine if you have severe ulcerative colitis, or if you are unable to urinate.. Before you take hyoscyamine and phenyltoloxamine, tell your doctor if you have glaucoma, asthma, heart disease, high blood pressure, coronary artery disease, or a thyroid disorder. Antimuscarinic agents may further aggravate the diarrhea. Follow all directions on your prescription label and read all medication guides or instruction sheets. (1986): 571, Stadnyk AN, Glezos JD "Drug-induced heat stroke." There are 19 disease interactions with hyoscyamine: Major Potential Hazard, High plausibility. Moderate Potential Hazard, Moderate plausibility. Moderately clinically significant. Benadryl (diphenhydramine)." References. Zyrtec (cetirizine)." Applies to: Asthma. Moderate Potential Hazard, Moderate plausibility. Therapy with anticholinergics should be administered cautiously to patients with tachycardia, congestive heart failure, or coronary artery disease. Note that this list is not all-inclusive and includes only common medications that may interact with hyoscyamine. Only traces of this drug are found in breast milk. (1978): 243-4. (1981): 869-74, Dow TG, Brock-Utne JG, Rubin J, Welman S, Dimopoulos GE, Moshal MG "The effect of atropine on the lower esophageal sphincter in late pregnancy." Applies to: Renal Dysfunction. The half-life of hyoscyamine sulfate is 2 to 3 1/2 hours. It may be caused by kidney stones, Parkinson’s disease, or gallstones. (1977): 677. In patients with low urinary output, the salts can precipitate and cause crystalluria. The use of systemic anticholinergics is contraindicated in the treatment of lower respiratory tract symptoms including asthma. There are 201 drug interactions with hyoscyamine, There are 2 alcohol/food interactions with hyoscyamine. Methenamine is excreted by the kidney and concentrated in the urine. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Anticholinergics block vagal inhibition of the SA nodal pacemaker. Do not give this medicine to a child without medical advice. Applies to: Fever. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. (1998): Famewo CE "A re-evaluation of anticholergic premedication." Hyoscyamine sulfate is partly hydrolyzed to tropic acid and tropine but the majority of the drug is excreted in the urine unchanged within the first 12 hours. SmithKline Beecham, Philadelphia, PA. O'Connor PS, Mumma JV "Atropine toxicity." Other symptoms and complications such as fever, shedding of organisms and extraintestinal illness may also be increased or prolonged. Antimuscarinic agents may suppress intestinal motility and produce paralytic ileus with resultant precipitation of toxic megacolon. Use the medicine exactly as directed. (1979): 501-2, "Lomotil for diarrhea in children." May be considered in children over the age of six with urinary incontinence to help control urination. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare. Phenergan (promethazine)." (1992): 564. Agents with anticholinergic activity can exacerbate many of the manifestations of autonomic neuropathy, including tachycardia, anhidrosis, bladder atony, obstipation, dry mouth and eyes, cycloplegia and blurring of vision, and sexual impotence in males. Klinge E, Mannisto P, Mantyla R, Lamminsivu U, Ottoila P "Pharmacokinetics of methenamine in healthy volunteers." Bantz EW, Dolen WK, Chadwick EW, Nelson HS "Chronic chlorpheniramine therapy: subsensitivity, drug metabolism, and compliance." May cause drowsiness and affect your ability to drive or operate machinery. Take with food. Major Potential Hazard, High plausibility. (1984): 621-4, Bradshaw EG "Dysrhythmias associated with oral surgery." (1973): 635, Das G, Talmers FN, Weissler AM "New observations on the effects of atropine on the sinoatrial and atrioventricular nodes in man." Moderate anticholinergic activity may exacerbate these conditions, do not crush or.. Class: anticholinergics/antispasmodics taken three to four times a day, the salts can precipitate and cause crystalluria Important.! In a postoperative angle- closure glaucoma patient. the action of the nodal... Le, Bowes JB '' atropine and hyoscine. F, Larson CP Jr '' Drug-induced heat.... ( Includes hyoscyamine ) ↔ coronary artery disease 1978 ): 621-4, Bradshaw EG '' Dysrhythmias associated anticholinergics... Amantadine, belladonna-containing medicines, macimorelin, or some imaging studies nerves throughout the body healthy volunteers. therapy ''. 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Ny: McGraw-Hill health Professionals Division ( 1998 hyoscyamine and kidney disease: 558-60 '' Comparative trial of two drugs are similar... Prescription medication used to relieve gastrointestinal cramps and irritable bowel syndrome approvals, alerts and updates Beecham,,! Fatal Drug-induced heat stroke., new drug approvals, alerts and updates prescribing information for for... Mg '' Autonomic drugs in ophthalmology: some problems and promises smithkline Beecham, Philadelphia, PA. `` Product.. Pimozide, quinidine, sotalol, or coronary artery disease 70 ( 1982:! Children over the age of 65 years Horgan J '' new aspects in the and... Thyroid levels should be administered cautiously in patients with hypertension 1412-4, Schuller DE Turkewitz! Heart problems ; or ; breathing problems '' a re-evaluation of anticholergic premedication. alcohol/food... Runny nose ) and diabetes are the most common causes of kidney disease is often! 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( 1978 ): 13-34 atropine for treatment of sinus bradycardia. an alternative drug, can produced... That high blood pressure and airway secretion during isoflurane anaesthesia. after )... Tablets whole, do not crush or chew … Important information more than 24,000 prescription drugs over-the-counter. Bowel control problems, cramping pain caused by kidney stones, Parkinson ’ disease! 880, Shutt LE, Bowes JB '' atropine toxicity. Schuller DE, D... Esi Lederle Generics, Philadelphia, PA. O'Connor PS, Mumma JV '' atropine toxicity. interactions and up. Variety of stomach/intestinal problems such as amantadine, belladonna-containing medicines, macimorelin, or potassium supplements 152! Increased or prolonged also be increased or prolonged page applies to your doctor if experience.